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Telomere length TL, telomerase activity TA and the presence of amyloid О peptide AО in plasma have emerged as possible predictors of cognitive decline and dementia. For example, shortening leukocyte telomere length has been linked to accelerated aging, as well as vascular, metabolic, and psychological risk factors for Alzheimers. For their part, plasma levels of AО have been associated with the risk of cognitive decline and conversion to dementia. However, studies to date have produced inconsistent results.