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The recent outbreak of Zika virus ZIKV, especially throughout Central and South America, revealed an unprecedented impact of gestational infection on neurodevelopment, resulting in severe consequences on central nervous system CNS development in newborns. born, such as the appearance of microcephaly and other abnormalities. Recent studies have shown that ZIKV predominantly infects neural stem and progenitor cells NPCs and disrupts key processes, such as survival, proliferation and differentiation, leading to massive cell death and growth reduction. At the operational level, the team is in a consolidation phase. At the Paoua hospital, for example, we need to organize the management of the pharmacy, set up a cold chain or even review the way in which medical statistical data is collected and compiled.
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4 versus 72. 9 at three years; hazard ratio for progression or death, 0. 35; 95 CI, 0. 22 to 0. 56; P 0. 001, and the results met the protocol-defined efficacy threshold for the interim analysis. Overall survival also favored ibrutinib-rituximab over standard therapy 98. 8 versus 91. 5 at 3 years; hazard ratio for death, 0.