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The study presents data up to 18 months post-immunization from an ongoing phase 3 double-blind randomized cifga NCT02747927 of the formulation in endemic regions of Asia and Latin America 26 medical and research centers in Brazil, Colombia, Philippines, Nicaragua, Panama, Dominican Republic, Sri Lanka and Thailand. Healthy children aged 4 to 16 years were randomly assigned 21 stratified by age and region to receive two doses of the formulation or placebo, 3 months apart. Investigators, participants and their parents or guardians, as well as sponsor representatives advising on the conduct of the trial were masked to trial group assignments. Participants presenting with febrile illness were tested for virologically confirmed dengue VCD by serotype-specific RT-PCR.
At time frames beginning 30 days after the second dose, the primary endpoint overall vaccine efficacy was assessed in the first 11 months, and the secondary endpoints efficacy by baseline HIV status, serotypedengue with hospitalization and severe cases in the cifga 17 months. On comptait environ 9 000 dГplacГs en ville, principalement regroupГs sur deux sites 6 000 personnes sur la paroisse de St-Laurent et 1 400 sur celle de St-Joseph. LвГquipe a dispensГ des consultations mГdicales et distribuГ des biens de premiГЁre nГcessitГ. Puis la tension en ville est retombГe, cifga les dГplacГs ont commencГ Г rentrer chez eux. LвГquipe MSF est partie de Bouar, a traversГ des villages incendiГs, pour rejoindre les populations cachГes en brousse ou dans leurs champs. Les gens sont terrorisГs et, Г chaque fois quвils entendent une voiture, ils senfuient, de peur de tomber sur des hommes armГs. Au total, en deux semaines dвintervention, cifga petite Гquipe mobile a dispensГ 2 000 consultations essentiellement pour des cas de paludisme et dinfections respirtatoires ; 30 concernaient des enfants ГgГs de moins de cinq ans.
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80CI, 0. 67 to 0. 96; low certainty, while calcium plus vitamin D increased the risk of stroke RR, 1. 17CI, 1. 05 to 1.