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The VKA DAPT therapeutic approach significantly increased bleeding when compared with most combinations e. versus VKA P2Y12 inhibitor OR 2. 11, 95 CI 1. 76 to 2. 52, p 0. 001. Of all combinations, apixaban plus P2Y12 inhibitor had the lowest risk of bleeding e. vs VKA P2Y12 inhibitor OR 0. 63, 95 CI 0. 51 to 0. 78, p 0. 001 and was classified as the best treatment. No significant differences in the ischemic outcome of major adverse cardiovascular events were observed between the various antithrombotic regimens. Le 30 juillet 2009, les deux parties parvenaient Г un accord au terme duquel Pfizer sengageait Г verser 75 millions de dollars Г lEtat de Kano. Dautres procГdures sont toujours en cours devant les tribunaux amГricains et le gouvernement fГdГral nigГrian continue dengager des poursuites judiciaires contre Pfizer.
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