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The aim of this systematic review was to evaluate the evidence on the safety and effectiveness of invasive procedures in reducing chronic pain, and improving function and health-related quality of life, compared with sham placebo interventions. Studies were identified by searching multiple electronic databases, examining reference lists, and by communicating with experts. We selected randomized controlled trials that compared invasive methods with identical but sham interventions for chronic conditions. Three authors independently extracted and described study characteristics and assessed risk of bias.
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