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Because the distance from health centers can be a major obstacle preventing people living with HIV from receiving their treatment. This is why the Ndhiwa project, jointly developed by MSF and the Kenyan Ministry of Health, brings together the Ndhiwa hospital, three health centers and 20 dispensaries, in a community approach and with local partners. Led by Claude Wischik of the University of Aberdeen, United Kingdom, the researchers conducted a 15-month double-blind, randomized, controlled, parallel trial conducted at 115 academic centers and private research clinics diclomax 16 countries in Europe, America North, Asia and Russia. The patients were people under 90 years of age with mild to moderate Alzheimers.

Participants who concomitantly used other AD medications were also included. However, those using medications with metahemoglobinemia warnings were excluded because the oxidized form of methylthioninium at high doses has been shown to induce this condition. Participants were then randomly assigned 334 to receive the following doses of LMTM 75 mg twice daily, 125 mg diclomax daily, or a control administration 4 mg LMTM twice daily. day to maintain blinding with respect to fecal or urine discoloration. Participants, their study partners usually caregivers, and all raters were masked to treatment assignment throughout the analysis.

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