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86 95 CI 0. 78 to 0. 94, I2 54, being similar whether it was measured according to dietary intake 0. 85, 0. 76 to 0. 96; I2 67 or as tissue biomarkers 0. 86, 0. 71-1. 03, I2 8. Subgroup analyzes also indicated that the inverse relationship between marine n-3 PUFAs and risk was more evident in studies that did not adjust for body mass index BMI 0. 74, 0. 64 to 0. 86, I2 0 than in those who did 0. 90, 0. 80 to 1. 01, I2 63. Dose-response analysis indicated that the risk of breast cancer was reduced by 5 per 0. 1gday 0. 95, 0. 90 to 1. 00; I2 52 or 0. 1 per energyday 0. 95, 0. 90 to 1.