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Patients previously underwent an average of five lines of treatments range 2-14. A total of 85 80 of the participants had been transplanted with autologous stem cells, 101 95 were refractory to the latest proteasome inhibitors and immunomodulatory drugs, and 103 97 were resistant to the latest line of therapy. Overall responses were observed in 31 cases 29. 2; 95 CI 20. 8 - 38. 9 three 2. 8, 0. 6 - 8. 0 had a strict CR, ten 9, 4, 4, 6 - 16. 7 had a very good PR and 18 17. 0, 10. 4 - 25. 5 a PR. The average time until the first response was 1 month range 0. 9 - 5. The median duration was 7. 4 months 95 CI 5. 5 - not estimable and progression-free survival was 3. 7 months 95 CI 2. 8 - 4.