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45 for evobrutinib 25 mg p 0. 32, 0. 30 for 75 mg once daily p 0. 005 and 0. 44 in the 75 mg twice daily group p 0. The unadjusted annualized relapse rate at week 24 was 0. 37 in controls, 0. 57 with 25 mg of the drug, 0. 13 with 75 mg daily, 0. 08 with 75 mg twice daily, and 0. 20 with DMF. There was no significant effect on change from baseline in EDSS score. Finally, elevations in hepatic aminotransferase values ввwere observed with treatment. For women, the whole issue often revolves around children. A woman may fear having more children because she had a uterine rupture and thought she was going to die. Another woman, after nine pregnancies, does not have a single living child.
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