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Tobias Janowitz and colleagues at the Feinstein Institutes for Medical Research Northwell Health New York, United States quantitatively assessed longitudinal changes in outcome measures reported by non-hospitalized COVID-19 patients who consumed high-dose oral famotidine. After the first administration, antibody-mediated responses were greater with a higher dose day 29 anti-S-2P antibody enzyme-linked immunosorbent assay geometric mean titer GMT, 40,227 in the 25-Оg group, 109,209 in the 100-Оg group -Оg, and 213,526 in the 250-Оg group. After the second immunization, the titers increased day 57 GMT, 299,751, 782,719, and 1,192,154, respectively. After the second application of the vaccine, serum neutralizing activity was detected by two methods in all participants. Solicited adverse events that occurred in more than half of people included fatigue, chills, headache, myalgia, and injection site pain. Systemic adverse events were more common after the second immunization, particularly with the higher dose, and three participants 21 in fastway 250 Оg group reported one or more serious adverse events.
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