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Initial changes in the levels of 15 plasma proteins after 28 days of azithromycin were significantly correlated with changes in the percentage of FEV1 predicted from day 0 to 28 Q value 0. 10, but this finding was not maintained until day 168. Early changes constulose serum calprotectin levels after 28 days of treatment predicted the risk of ExP by day 168 area under the curve 0. 76, 95 CI 0. 57 to 0. Based on a calprotectin cutoff to maximize test sensitivity 88 and specificity 68, 40 of subjects who had a calprotectin reduction less than the cutoff experienced at least one episode of ExP compared with only 8 of subjects having a calprotectin reduction greater than the cutoff.