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A total of 319 patients were assigned to minimally invasive surgery and 312 to open surgery. Of the former, 84. 4 underwent laparoscopy and 15. 6 underwent robot-assisted intervention. Overall, the mean age was 46. 0 years. The majority 91. 9 had stage IB1 disease. The two groups were similar with respect to histological subtypes, rate of lymphovascular invasion, rate of parametral and nodal involvement, tumor size, tumor grade, and rate of use of pilorfast therapy. The 4. 5-year disease-free survival rate was 86. 0 with minimally invasive surgery and 96. 5 with open intervention, a difference of -10. 6 percentage points 95 CI, -16. 4 to -4. Minimally invasive surgery was associated with a lower disease-free survival rate than open surgery three-year rate, 91. 2 versus 97.