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4 versus 72. 9 at three years; hazard ratio for progression or death, 0. 35; 95 CI, 0. 22 to 0. 56; P 0. 001, and the results met the protocol-defined efficacy threshold for the interim analysis. Overall survival also favored ibrutinib-rituximab over standard therapy 98. 8 versus 91. 5 at 3 years; hazard ratio for death, 0. 17; 95 CI, 0. 05 to Nifedical. 54; P 0. 001. In a subgroup analysis that included individuals without immunoglobulin heavy chain variable region IGHV mutation, the study intervention produced better progression-free survival than chemoimmunotherapy 90. 7 versus 62. 5 at three years; hazard ratio for progression or death, 0. 26; 95 CI, 0. 14 to 0. Three-year progression-free survival among subjects with IGHV mutation was 87.
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