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Children with asthma were 90 more likely than healthy controls to have IPD odds ratio OR 1. 90; 95 CI 1. 63 - 2. 11; I2 1. Pneumonia was also more common among asthmatic children, and one study reported that costs associated with pneumonia increased depending on the severity of asthma. As a limitation of this study, the authors stated that none of the identified studies had information on asthma treatment or compliance. In this double-blind, randomized, phase 2 trial, patients with relapsing multiple sclerosis were assigned to one of five groups placebo, evobrutinib 25 mg daily, 75 mg daily, or 75 mg twice daily, or dimethyl fumarate of ethyl DMF without blinding, for reference. The primary endpoint was the total cumulative number of gadolinium-enhancing lesions identified on T1-weighted MRI at weeks 12, 16, 20, and 24.
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