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The most robust and validated association is that of a missense variant in PNPLA3 Patatin-like phospholipase domain-containing protein 3. This alternative form rs738409, p. I148M is related to the presence of higher levels of hepatic triglycerides and a high risk of non-alcoholic steatohepatitis and cirrhosis. However, the underlying mechanisms have not yet been elucidated, and much of the genetics of chronic liver disease remains underexplored. In women going through their first gestational stage, the volume of gray matter is reduced in regions involved in social relationships, changes that would last at least two years. In analyzes adjusted for age, sex, and years of education, the three risnia variables separately showed a statistically significant association with mortality.
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