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9; P 0. 001. The percentage of individuals who did not have the most bothersome symptom two hours after administration was 37. 6 for rimegepant and 25. 2 for controls absolute difference, 12. 4 percentage points; 95 CI 6. 9 to 17. 9; P 0. 001. The most frequent adverse events were nausea and urinary infection. This study evaluated the efficacy and safety of an investigational therapy for severe VKC, using a cationic emulsion CE of cyclosporine A CsA, an oil-in-water emulsion that exhibits increased bioavailability compared to conventional CsA formulations. To this end, a phase 3, multicenter, double-blind, vehicle-controlled trial VEKTIS, VErnal KeratoconjunctiviTIs was conducted.
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