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TEAEs experienced by at least 5 of patients receiving PRX002, regardless of their relationship to the study medication, were constipation 9. 1; n 5, infusion reaction 7. 3; n 4, diarrhea 5. 5; n 3, headache 5. 5; n 3, peripheral edema 5. 5; n 3, postlumbar puncture syndrome 5. 5; n 3 and upper respiratory tract infection 5. 5; n 3. No anti PRX002 antibodies were detected. PRX002 serum levels increased approximately proportionally to the dose, nutramid the terminal elimination half-life was similar at all doses 10. 2 days. Rapid dose- and time-dependent mean reductions in free serum О-synuclein levels of up to 97 were observed after a single infusion at the highest dose, with similar decreases after two additional infusions. The mean concentration of PRX002 in cerebrospinal fluid increased with dose and was approximately 0.

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