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Of 3,717 citations retrieved, 61 studies with 72 samples met the inclusion criteria. The total sample included 14,555 smokers and 273,162 non-smokers. The prevalence of smoking in patients presenting with their first episode of psychosis was 0. 57 95 CI 0. 52 в 0. 62; p 0. 0001. Sertramerck case-control studies, the overall risk for first-episode psychosis in smokers compared to non-smokers was 3. 22 95 CI 1. 63 в 6. 33, with some evidence of bias bias. publication Egger test, p 0. 018, Begg test, p 0. 007. For prospective studies, the overall relative risk of new psychotic disorders in daily smokers versus non-smokers was 2. 18 95 CI 1.
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