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05 for treated interquartile range, -0. 71 to 0. 92 and 0. 17 for placebo interquartile range, -0. 62 to 0. 89, P 0. Interestingly, the average weight gain during gestation was lower for those who received the drug 4. 6 kg interquartile range, 1. 3 to 7. 2 versus 6. 3 kg for controls interquartile range, 2. 9 a 9. 2, P 0. 001. The same phenomenon was evident with the incidence of preeclampsia 3. 0 vs. 3; R 0. 24; 95 CI 0. 10 - 0. 61; P 0. 001. On the other hand, side effects were greater in the metformin group than in the controls. Finally, there were no significant differences in the incidences of gestational diabetes, large-for-age newborns, or adverse neonatal outcomes.
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